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37648 – A treatment for spinal muscular atrophy. Spinal Muscular Atrophy (SMA) is caused by deletion or mutation of SMN1 and retention of SMN2, this in turn leads to reduced levels of the full SMN protein. SMA is the second leading cause of neuromuscular disease, and many people living with SMA need round-the-clock care from their families and also from a variety of medical specialists. This... Read More
39545 – Self-assembling, highly stable RNA cages amenable to custom functionalization and cargo delivery One of the primary challenges in therapeutic development is cheap, efficient, and safe drug delivery to specific target tissues. To better target specific tissues, RNA nanotechnology has been progressively applied to generate predefined architectures via self-assembly of modular building... Read More
37746 – Innovative thermogenic biologicals, methods of delivery, and combinational therapy for the treatment of abdominal obesity Obesity as a result of an increase in intra-abdominal (or visceral) fat is an independent risk factor for major diseases such as type 2 diabetes and cardiovascular diseases due to increases in insulin resistance and chronic inflammation. Accumulation of... Read More
37787 – Nanostructures that enhance the stability of biocatalysts that permit them to be utilized in scalable CO conversion processes Carbon dioxide (CO) and methane (CH) are the two most abundant greenhouse gasses, trapping thermal radiation close to the earth’s atmosphere and contributing to climate change. These two gasses contributed up to 92% of all the greenhouse gas emissions in 2015... Read More
37707 – An efficient delivery vehicle for therapeutic oligonucleotides with high efficiency. The Need MiRNA or miRs are small non-protein coding RNA which are capable of regulating mRNAs in multiple biological pathways, including those involved in cancer development and wound healing. Antagomirs, also known as anti-miRs, inhibit miR activity and could be used to develop therapeutics for... Read More
14913 – A novel methodology for the production of polymeric particle-like drug delivery devices Currently, the six common drug delivery mechanisms are oral, topical, injection, pulmonary administration, transmucosal, and transdermal. Advanced drug delivery include sustained/extended release, prodrugs, targeted, polymeric, implants, and IUDs. Polymeric drug delivery systems are provide a... Read More
37370 – A novel method to introduce targeted therapy to individual cells with perfect cell viability and transfection. Precise delivery of nucleic acids is highly valuable for in vitro biomedical research, such as drug discovery, cell-drug biology, and cancer therapy. Controlled delivery of large gene molecules has the potential for highly efficient transfection of stem cells and pluripotent... Read More