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37677 – A mechanism by which the inhibiting efects of drugs and other molecules on protein-protein interactions can be measured. Protein-protein interactions (PPIs) occur when two or more proteins bind together, and they represent a large group of drug targets. However, PPIs are difficult to disrupt because they usually involve large, two-dimensional target surfaces. Conventional small... Read More
32418 – A combination-therapy that has the potential to overcome and/or prevent the commonly observed acquisition of sorafenib resistance, which is associated with treatment failure in patients with hepatocellular carcinoma. Hepatocellular carcinoma (HCC) kills nearly all patients within a year of diagnosis, and results in between 250,000 and one million deaths globally per year. In the US,... Read More
38998 – Parthenolide analogues derived from plants could be effective in treating leukemia or supplementing other treatments. The American Cancer Society estimates that in 2017 there will be about 1,688,780 new cancer cases diagnosed and 600,920 cancer deaths in the United States. Chemotherapy has improved, but further development is needed to improve the efficacy of this treatment, and... Read More
38701 – Small-molecule prodrugs that target IL-6/STAT3 signaling pathway. Multiple Sclerosis (MS), an unpredictable and disabling autoimmune disease affecting the central nervous system, is the leading cause of non-traumatic neurological disability in young adults. There have been important advances in MS therapy, such as drugs that slow the progression of the disease and reduce attacks, but... Read More
14936 – Small molecule modulators of Clavibacter michiganensis subsp. michiganensis (Cmm) as a means to control tomatobacterial canker. Current efforts to control tomato cankers rely heavily on copper bactericides and antibiotics. These methods have significant limitations in that they exhibit limited efficacy in treatment and may promote pathogen resistance. Common strategies for controlling... Read More