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32588 – Engineered calmodulin-based therapeutics for the treatment of cardiovascular diseases. While there are three ryanodine receptors responsible for the release of calcium from intracellular stores during excitation-contraction, ryanodine receptor channel 2 (RyR2) has emerged as an important target in the treatment of cardiac failure. When RyR2 channels cease to effectively regulate... Read More
14945 – A novel plasmid addiction system for cost-effective end-product generation. The fermentative production of biobutanol through the use of Clostridium is a well-known process and utilized for production of solvents and fuels. However, problems with this method include difficulty in genetically manipulating native strains, scalability for industrial applications, and low yields.... Read More
37747 – Identification and use of novel adipokines for reduction of visceral fat using thermogenesis. Obesity as a result of an increase in intra-abdominal (or visceral) fat is an independent risk factor for major diseases such as type 2 diabetes and cardiovascular diseases. Risk is increased with higher levels of intra-abdominal fat due to increases in insulin resistance and chronic... Read More